To abandon hope; be or become hopeless; often with of.
Utter hopelessness.
That which causes despair or which is despaired of.
Despairingly.
And so, if we fail, we need not despair. – The Soul of a People by H. Fielding
I had given up in despair seeing you to- day. – The Sign of Flame by E. Werner
All that day Keith Macleod was in despair. – Macleod of Dare by William Black